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Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize

Received: 11 September 2019     Accepted: 7 October 2019     Published: 17 October 2019
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Abstract

A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.

Published in Science Journal of Chemistry (Volume 7, Issue 4)
DOI 10.11648/j.sjc.20190704.11
Page(s) 72-76
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Isoxaflutole, Metabolites, Maize, Method, Residues

References
[1] Pallett K E, Little J P, Sheekey M, et al. The mode of action of isoxaflutoleI. physiologicaleffects, metabolism, and selectivity [J]. Pesticide Biochemistry and Physiology, 1998, 62 (2): 113-124.
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[3] https://www.ecfr.gov/cgi-bin/retrieveECFR?gp=1&SID=e8a5b861d874af20b816afd7f193bbfb&ty=HTML&h=L&mc=true&r=SECTION&n=se40.26.180_1537
[4] http://db.ffcr.or.jp/front/pesticide_detail?id=6700
[5] https://ec.europa.eu/food/plant/pesticides/eu-pesticides-database/public/?event=pesticide.residue. CurrentMRL&language=EN
[6] Lin C H, Lerch R N, Thurman E M, et al. Determination of isoxaflutole (balance) and its metabolites in water using solid phase extraction followed by high-performance liquid chromatography with ultraviolet or mass spectrometry [J]. Journal of Agricultural and Food Chemistry, 2002, 50 (2): 5816-5824.
[7] Lin C H, Lerch R N, Thurman E M, et al. Improved HPLC-MS/ MS method for determination of isoxaflutole (balance) and its metabolites in soils and forage plants [J]. Journal of Agricultural and Food Chemistry, 2007, 55 (10): 3805-3815.
[8] Rouchaud J, Neus O, Eelen H, et al. Siol metabolism of isoxaflutole in corn [J]. Archives of Environmental Contamination and Toxicology, 2002, 42 (3): 280-285.
[9] Yang C Z, Wang C S, Cheng Y, et al. Determination of isoxaflutole and its metabolite residues in maize by HPLC-MS/MS [J]. Food Science, 2011, 32 (22): 280-284.
[10] National Health and Family Planning Commission of the People's Republic of China, The Ministry of Agriculture of the People's Republic of China. National food safety standard-Maximum residue limits for pesticides in food [S]. Beijing: Standards Press of China, 2016.
[11] Liu X G, Xu J, Li Y B, et al. Rapid residue analysis of four triazolopyrimidine herbicides in soil, water, and wheat by ultraperformance liquid chromatography coupled to tandem mass spectrometry [J]. Analytical and Bioanalytical Chemistry, 2011, 399 (7): 2539-2547.
[12] Liu N, Dong F S, Xu J et al. Determination of Aminoglycoside Fungicide Validamycin A in Rice Plant by Quick, Easy, Cheap, Effective, Rugged, and Safe Approach Using Ultra High Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry [J]. Food Analytical Methods, (2016) 9: 1736-1744.
[13] Chen X X, Dong F S, Xu J, et al. Enantioseparation and determination of isofenphos-methylenantiomers in wheat, corn, peanut and soil with Supercritical fluidchromatography/tandem mass spectrometric method [J]. Journal of Chromatography B, 1015–1016 (2016) 13–21.
[14] Feng Y Z, Li Y Jin J, et al. Determination of LH-2010A residues in potato and soil [J]. Chinese Journal of Pesticide Science2017, 19 (6): 760-764.
[15] Cao J L, Liu X G, Dong F S et al. Residues and decline dynamics of thifluzamide in rice field [J]. Chinese Journal of Pesticide Science, 2017, 19 (1): 84-92.
[16] He M, Song D, Dong F S, et al. Determination of fipronil and its metabolites in leek and soil by ultrahigh performance liquid chromatography-mass spectrometry [J]. Environmental Chemistry, 2016, 35 (5): 925-932.
Cite This Article
  • APA Style

    Mao Jia, Feng Yizhi, Qi Xiaoxue, Han Jifeng, Pan Jinju, et al. (2019). Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Science Journal of Chemistry, 7(4), 72-76. https://doi.org/10.11648/j.sjc.20190704.11

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    ACS Style

    Mao Jia; Feng Yizhi; Qi Xiaoxue; Han Jifeng; Pan Jinju, et al. Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Sci. J. Chem. 2019, 7(4), 72-76. doi: 10.11648/j.sjc.20190704.11

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    AMA Style

    Mao Jia, Feng Yizhi, Qi Xiaoxue, Han Jifeng, Pan Jinju, et al. Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Sci J Chem. 2019;7(4):72-76. doi: 10.11648/j.sjc.20190704.11

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  • @article{10.11648/j.sjc.20190704.11,
      author = {Mao Jia and Feng Yizhi and Qi Xiaoxue and Han Jifeng and Pan Jinju and Liang Lin and Liu Wei and Zuo Bojun},
      title = {Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize},
      journal = {Science Journal of Chemistry},
      volume = {7},
      number = {4},
      pages = {72-76},
      doi = {10.11648/j.sjc.20190704.11},
      url = {https://doi.org/10.11648/j.sjc.20190704.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190704.11},
      abstract = {A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize
    AU  - Mao Jia
    AU  - Feng Yizhi
    AU  - Qi Xiaoxue
    AU  - Han Jifeng
    AU  - Pan Jinju
    AU  - Liang Lin
    AU  - Liu Wei
    AU  - Zuo Bojun
    Y1  - 2019/10/17
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sjc.20190704.11
    DO  - 10.11648/j.sjc.20190704.11
    T2  - Science Journal of Chemistry
    JF  - Science Journal of Chemistry
    JO  - Science Journal of Chemistry
    SP  - 72
    EP  - 76
    PB  - Science Publishing Group
    SN  - 2330-099X
    UR  - https://doi.org/10.11648/j.sjc.20190704.11
    AB  - A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.
    VL  - 7
    IS  - 4
    ER  - 

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Author Information
  • Institute of Agriculture Environment and Resource, Yunnan Academy of Agricultural Sciences, Kunming, China

  • Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

  • Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

  • Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

  • Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

  • Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

  • Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

  • Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

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